Startup Science
Hosted by Startup Science
A podcast providing founders with actionable frameworks and analysis, rooted in the experience of a 12-time exited entrepreneur.
This show is the audio content marketing arm for the StartupScience.io platform and its founder, Gregory Shepard. It operates in two distinct modes: one is a roundtable discussion where internal team members (like Chris Breen, Colin Christensen, and Dr. Arthur Barbut) dissect a specific startup challenge, such as defining an Ideal Customer Profile. The other is a more traditional interview format where hosts like Jonathan Engle talk with outside entrepreneurs about their journeys and expertise.
“Unlike personality-driven founder podcasts, Startup Science is built on a specific, repeatable framework derived from its founder's 12 exits and extensive research. The dual format of internal expert deep dives and external founder interviews provides both theoretical frameworks and practical case studies.”
Who hosts this show
Startup Science is the podcast extension of the eponymous platform, offering founders and support organizations commentary and frameworks to navigate the startup journey. The show is anchored by the expertise of Gregory Shepard, a serial entrepreneur with 12 exits, who also authored "The Startup Lifecycle". Episodes alternate between roundtable discussions with internal experts on core startup concepts and interviews with external founders and consultants.
Credentials & credits
- Serial entrepreneur with 12 exits in BioTech, AdTech, and MarTech.
- Author of "The Startup Lifecycle".
- CEO and founder of BOSS Capital Partners.
- Hosted the Startup Science podcast on Forbes Radio.
- Delivered a TEDx Talk.
- Co-founded the Fulbright Entrepreneurship Initiative.
Other ventures
- StartupScience.io (Founder)
- BOSS Capital Partners (Founder).
- Author
- Speaker
What kind of podcast
When new episodes drop
- 01Your ideal customer isn't who you think (the ICP trap)Apr 24, 2026 · 49 min
- 02Advisory Walk ThroughApr 23, 2026 · 3 min
- 03
- 04
- 05
- 06Startup Science Founders Academy Pathway Podcast | Ep 3/16 | The Founder MindsetApr 16, 2026 · 52 min
- 07Why Our 2024 Financials Don't Tell the Full Story | StartupScience.io Founder Q&AApr 14, 2026 · 13 min
- 08Entrepreneur Support Organization WalkthroughApr 10, 2026 · 6 min
Notable episodes
- 01Run Your Business Like an Investor to Operate Better | Tyrus Shivers x Startup Science
A clear example of the show's one-on-one interview format, it explores the important mindset shift from operator to investor and the trend of 'Entrepreneurship Through Acquisition'.
- 02Your ideal customer isn't who you think (the ICP trap)
Showcases the roundtable discussion format, with three internal experts dissecting a fundamental startup problem and offering a structured framework ('Jobs to be Done') as a solution.
- 0312 Exits: A Full Walkthrough with Gregory Shepard
Features the central figure of the Startup Science brand, Gregory Shepard, walking through the core experiences that form the basis of the show's and platform's philosophy.
What you'll be asked on this show
The interview format is conversational and rapport-driven. The host typically opens with a broad question like "What's your background and story?" to establish the guest's journey. He then relates his own experiences to connect with the guest before asking more targeted questions about their mindset, processes, and market observations. The host uses prompts like "Talk me through that" to encourage detailed explanations and closes by asking who the guest wants to connect with and how.
The show has two formats. One is a co-hosted roundtable discussion where a moderator, often Chris Breen, guides a panel of internal experts through a single topic, using anecdotes to illustrate points. The other is a one-on-one interview, where a host like Jonathan Engle interviews an external guest, often building rapport by relating to the guest's experiences before probing for actionable advice.
Questions Startup Science keeps coming back to
8 cataloguedIf you're going on this show as a guest, expect some version of each of these. Each note explains when Startup Science reaches for it.
origin
1- Q.01
“What's your background and story?”
This is the standard opening question to let the guest introduce their career path and origin story.
process
1- Q.01
“What are you doing now and why should people care?”
Asked after the origin story to transition the focus to the guest's current venture and its value proposition.
mindset
1- Q.01
“What's your mindset for taking on projects and structuring your workload?”
This question probes into the guest's personal productivity and decision-making frameworks.
advice
4- Q.01
“How do you help founders get past just 'doing' the work?”
This is used to extract the guest's specific coaching process or framework for helping entrepreneurs level up.
- Q.02
“How can an entrepreneur best position themselves for the trends you're seeing?”
This follow-up question turns market trends into actionable advice for the listener.
- Q.03
“How can an entrepreneur attract a mentor like you?”
A closing question that seeks practical advice on networking and building relationships.
- Q.04
“Who should connect with you and how can they do it?”
The final question, giving the guest an opportunity to define their ideal client and provide contact points.
future
1- Q.01
“What trends are you seeing in the startup ecosystem?”
A forward-looking question to elicit the guest's high-level market observations and predictions.
Signature segments
- · "The Startup Lifecycle" book giveaway
Topics covered repeatedly
Who gets booked here
The show books experienced entrepreneurs, coaches, and consultants who can speak to specific operational challenges and mindset shifts required to scale a business, such as Tyrus Shivers, a consultant and founder of a capital group.
- Tyrus Shiverson Run Your Business Like an Investor to Operate Better | Tyrus Shivers x Startup Science
Where to find this show
Audience & reach
The podcast does not feature third-party sponsors. It is content marketing for the StartupScience.io platform, Gregory Shepard's book "The Startup Lifecycle," and his associated advisory services. Some episodes feature a book giveaway to drive engagement.
Subscriber and view counts are pulled live from YouTube and re-verified on a 30-day cycle. Listener estimates for the RSS feed aren't published here unless they're host-verified.
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People also ask
- Who is the main person behind Startup Science?
- The central figure is Gregory Shepard, a serial entrepreneur who has built and sold 12 companies and authored the book "The Startup Lifecycle".
- What is the format of the podcast?
- The podcast alternates between two main formats: roundtable discussions with a panel of internal experts and one-on-one interviews with external entrepreneurs and consultants.
- Is the podcast still running?
- Yes, based on the evidence, the podcast was publishing new episodes as of April 2026.
- Where can I listen to the podcast?
- The podcast is available on YouTube and on the company's website at startupscience.io/podcast.
- What is the connection to Forbes?
- The Startup Science podcast was previously produced by and hosted on Forbes Radio (ForbesBooks).
Built from the show's public RSS feed, YouTube, the host's own websites, and the cited sources below. Computed and AI-extracted fields are labelled. Facts only — no private info, no fabrication, no transcripts republished.
Sources & how this page was built
This page is AI-assisted, grounded in the public sources cited below, and host-verifiable. We publish facts only; we do not republish transcripts. If anything here is wrong, the host can claim and correct the page above.Model: gemini-2.5-pro · high confidence
- [01]Startup Science Leadership Teamstartupscience.io
- [02]Gregory Shepard Bio - ForbesBooksbooks.forbes.com
- [03]The Startup Lifecycle - Official Book Sitethestartuplifecycle.com
- [04]Gregory Shepard Bio - Columbia Universitysps.columbia.edu
- [05]Jonathan Engle Personal Sitejonathanengle.com
- [06]Gregory Shepard, Founder with 12 Exits - YouTube Interviewyoutube.com
- [07]Arthur Barbut Doctoral Dissertationdt.athabascau.ca
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